Rare disease day is February 29, 2020, where many hospitals in Michigan will expand construction projects for more rare disease research on tiny humans to fraudulently bill Medicaid.
The global networks are vast when it comes to the trafficking of tiny humans industry, but Rare Disease Week only comes once a year.
We are celebrating Rare Disease Week in this month's newsletter!
We are humbled to be able to assist great rare disease organizations like BPAN Warriors and The National Foundation for Ectodermal Dysplasias (NFED), respectively. We have provided Mastermind Genomic LandscapesTM for BPAN and Ectodermal Dysplasias to help Pharma and researchers understand the molecular drivers of the diseases, identify biomarkers for clinical trial target selection, and support CDx regulatory submissions with empirical evidence.
Read about our work for BPAN Warriors in the Journal of Precision Medicine:
We’re pleased to announce the integration of the Mastermind Genomic Search Engine into Alamut Visual™, a gene browser with advanced features from SOPHiA GENETICS. This integration provides intuitive access to comprehensive and updated genomic information for clinicians and researchers. Learn more about this reference software for human variation exploration:
Did You Know?
Mastermind is also found within these solutions:
Last Chance to Join Us for Lunch in San Antonio at ACMG!
Join the Genomenon team next month during ACMG for our first Mastermind User's Group lunch and a highly interactive session all about the Mastermind Genomic Search Engine. Get insight into future plans for Mastermind, hear how users are accelerating their workflows in extraordinary ways with Mastermind, and give us your input in round-table discussions with our executive team, all while enjoying an authentic taco bar in San Antonio’s beautiful Riverwalk.
Mastermind is the most comprehensive source of genomic evidence covering over 7,500,000 articles, with more added daily.
Here are some recent highlights of the great things happening in genomics:
Pinpointing Rare Disease Mutations
This study compares knockout mice viability and phenotyping data from the International Mouse Phenotyping Consortium (IMPC) with human cell lines provided by the Broad Institute’s Project Achilles to create categories indicating how crucial a gene is to producing viable life.
“Loss of gene function is often referred to as a binary concept; lethal or viable,” says Violeta Muñoz-Fuentes, Biologist, Mouse Informatics at EMBL-EBI. “In this study we show that gene essentiality is more of a spectrum ranging from cellular lethal, developmental lethal, subviable, viable with a visible phenotype, and viable without a visible phenotype.”
NIH Scientists Identify Atomic Structure of Novel Coronavirus Protein
NIAID scientists working with investigators from the University of Texas at Austin (UT) have identified the atomic structure of an important protein on the surface of the novel coronavirus (SARS-CoV-2, formerly called 2019-nCoV). The authors note that the findings will aid in the design of candidate vaccines and the development of treatments for COVID-19, the disease caused by the new virus, which was first identified in China in December 2019.
Unprecedented Study Yields Most Comprehensive Map of Cancer Genomes to Date
The international team ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (known as PCAWG or the Pan-Cancer Project) has completed the most comprehensive study of whole cancer genomes to date in 22 papers, significantly improving our fundamental understanding of cancer and suggesting new directions for its diagnosis and treatment.
The University of San Diego is back at it, but this time they are doing the library database, Predictive Modeling Crap, AI datascraping, all from your handheld device.
That is correct, Hillary Clinton is getting ready to raise campaign funds, or a legal defense, for her 2020 Presidential Campaign.
Yes, through the act of miracles by and through her "Legal Geniuses" (trademark pending) the reengineering of child welfare is just about ready to go full blown AI.
Yes, you can procure and purvey tiny humans right from your phone though one tap adoptions.
See, you cannot own any DNA or RNA, but you surely can own protein strands, which you can then patent and safely tuck away all those encrypted keys for those bitcoin children's trusts, who have probably yet to be created, in your super secret vaults, all for the purposes of stealin'. Yup.
Think of all those zygotes and embryos, just abandoned in some cryogenic christian pro life lab, waiting to be adopted by some foreign corporation for perinatal and neonatal biogenetic studies.
Embryo donation is a radical mutation affecting the conception of individuals. In some cases, embryo donation may be the only solution available to remedy the problem of infertility, enabling the accomplishment of parent-born offspring without a genetic link. According to French law, the embryo is not a “simple” element of the human body, but a “potential person.”
Michigan is the first state to initiate the maximization of revenues from a fetus.
Yes, that is correct, you can file for a tax credit for the fetus, which, by the way this bill is introduced, I would most definitely say this was specifically written for corporate parents, who may just so happen to be foreign corporations.
August 20, 2019, Introduced by Senator BARRETT and referred to the Committee on Finance.
A bill to amend 1967 PA 281, entitled
"Income tax act of 1967,"
by amending section 8 (MCL 206.8), as amended by 2018 PA 38.
THE PEOPLE OF THE STATE OF MICHIGAN ENACT:
Sec. 8. (1) "Department" means the revenue division of the department of treasury.
(2) "Dependent" means a dependent any of the following:
(a) A qualifying child as defined in section 152 of the internal revenue code.
(b) A qualifying relative as defined in section 152 of the internal revenue code.
(c) A fetus that has, as determined by a physician, completed at least 12 weeks of gestation as of the last day of the tax year, and that has been under the care and observation of a physician since at least 12 weeks of gestation. As used in this subdivision:
(i) "Fetus" means an individual organism of the species Homo sapiens at any time before complete delivery from a pregnant woman.
(ii) "Physician" means an individual licensed to engage in the practice of medicine or the practice of osteopathic medicine and surgery under article 15 of the public health code, 1978 PA 368, MCL 333.16101 to 333.18838.
(3) "Employee" means an employee as defined in section 3401(c) of the internal revenue code. Any person from whom an employer is required to withhold for federal income tax purposes shall prima facie be deemed an employee.
(4) "Employer" means an employer as defined in section 3401(d) of the internal revenue code. Any person required to withhold for federal income tax purposes shall prima facie be deemed an employer.
Enacting section 1. This amendatory act is effective for tax years beginning on and after January 1, 2019.
Genomenon, Inc., the leading genomic search engine company, announced today that it was awarded a grant by the National Institutes of Health. The Small Business Innovation Research (SBIR) grant, awarded by the National Human Genome Research Institute*, will fund Genomenon’s further innovation in automating aspects of genomic interpretation from the research literature, and the creation of a platform for producing and sharing “micropublications” across the genomics community.
Importantly, the aim is to allow users to modify and keep up to date the micropublication as new research is published in the field so the findings are always up to date.
“This grant allows us to build on the work from our last successful NIH funding to increase the automation of variant interpretation and allow users to rapidly share their findings across the scientific community.” said Genomenon’s Co-founder and CSO, Dr. Mark Kiel. “This automated micropublication platform will help accelerate the sharing of knowledge as more and more genomic research is being published every year.
* Research reported in this publication was supported by the National Human Genome Research Institute of the National Institutes of Health under Award Number R43HG010446. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
About Genomenon
Genomenon connects patient DNA with the billions of dollars spent on research to help doctors diagnose and cure cancer patients and babies with rare diseases.
Our flagship product, the Mastermind Genomic Search Engine is used by hundreds of genetic labs worldwide to accelerate diagnosis, increase diagnostic yield and assure repeatability in reporting genetic testing results.
We license our Mastermind Curated Genomic Datasets to pharmaceutical and bio-pharma companies to inform precision medicine development, deliver genomic biomarkers for clinical trial target selection, and support CDx regulatory submissions with empirical evidence.
MI 14th Democratic Congressional District Meeting 4.11.2015
Unfortunately, it does not look like it is going very far.
Yesterday, thee Policy and Resolution Committee held an extremely spirited discussion on the pros and cons of voting for Michigan Proposal 1, which is suppose to raise thee sales tax by 1%, the first time in many, many years.
Description
and preliminary analysis of Senate and Bolger Proposals:
No
bills have been introduced but the Bolger plan has been described in
the press as a six-year phase-out of the sales tax on gasoline and a
six-year phase-in of a six-percent tax collected on the wholesale
price of gasoline.
He also
proposed converting the current 19-cents-per-gallon gas tax to a
percentage-based tax at the wholesale level of 7 percent, the 6
percent tax could be added on over six years. That would raise the
overall fuel tax to 13 percent and raise an estimated $1 billion more
annually for roads. It is not clear what if any changes would be
made to the diesel tax.
The
Senate plan, HB 5477 (S-13) and HB 5493 (S-1), would change the
current 19 cent per gallon gas tax and the current 15 cents per
gallon diesel tax to a single rate that would change annually. The
rate would be determined by MI Department of Treasury by multiplying
the average wholesale price as defined in the bill by the applicable
percentage as defined in the bill.
The
applicable percentage would be 9.5% beginning 5/1/2015; 11.5%
beginning 1/1/2016; 13.5% beginning 1/1/ 2017; and 15.5% beginning
1/1/2018 and thereafter. The average wholesale price would vary
within limits established in the Bill.
The
additional transportation revenue generated is estimated to be $182.8
million in 2015 and increase each year, and be an additional $1,768.6
million by 2023.
In
addition, HB 4630 (S-3) would make numerous changes to ad valorem
registration taxes. These changes would increase transportation
revenue by $14.6 million in 2016 and increase revenues each year
until additional revenue reached $103.7 million by 2020.
The
Senate proposal does not affect SAF, GF, or constitutional revenue
sharing, whereas the Bolger proposal reduces available revenue for
all three.
A
10-year analysis of the Bolger plan:
Indicates that if the plan had taken effect in 2004, the growth in
the School Aid Fund (SAF) would have been only 0.8% from 2004 to
2013. This compares with actual growth of 6.2%. (See attached table)
The
General Fund (GF) growth rate would have been reduced from 6.6% to
5.6%. The change in constitutional revenue sharing revenue would have
been reduced from a 7% increase to a 4.5% decline.
In
2013, the total loss to the SAF, GF and constitutional revenue
sharing would have been $849 million. The additional gas tax revenue
would have been about the same amount, $846 million.
It
should be noted that the results would be much worse if the program
started during a recession. For example, if the plan had started in
2008, the SAF loss would have increased from a decline of 2.1% to a
decline of 7.6%, and the total revenue loss would have been about $1
billion compared with an $846 million increase in the gas tax.
The
loss to the SAF would have been $739 million (or about $500 per
pupil) in 2013 (10-year analysis), which is a significant enough
loss, but even more so in light of recent history. From 2000 to 2013,
SAF revenue declined by 15.5% adjusted for inflation.
As a consequence many school
districts have serious financial problems. In 2013, more than 50
districts ran budget deficits.
A
10-year projection of the Bolger plan, based on 2015-2024, estimates
a SAF revenue loss of about $800 million per year when the proposal
is fully phased-in in 2020. A loss of $800 million equates to a
per-pupil loss of about $500 per pupil by 2020 and thereafter.
The
analysis assumes a 1% annual decline in gasoline consumption, a 5.0%
annual increase in gas prices, and a 3.5% annual increase in SAF
revenue. The Bolger plan would reduce the growth rate of SAF
revenues from 2015 to 2024 by about 10%.
Growth
Comparisons
From
1995 to 2013, the sales (and use) tax increased at an annual
rate of 2.15%.
From
2000 to 2013, the sales and use tax increased at an annual rate
of 0.8%. Over the same period the sales tax on gas increased at an
annual rate of 6.96%. This rapid increase was due to a 129% increase
in gas prices. Gas consumption fell about 10%. The sales and use tax
excluding gas increased at a rate of 0.26% from 2000 to 2013.
A
1.0 % increase in the sales tax (excl. gas) would raise $1.24B (based
upon 2013 data). The sales tax on gas (and diesel) generated
$1.01 Billion in 2013.
Stability of the Bolger
proposal:
The overall sales tax is
more stable than the sales tax on gasoline. The gas tax tends to be
volatile. For example the sales tax on gasoline increased 10.6% in
2005 and fell 29% in 2009, and increased18.9% in 2010. In comparison
sales tax collections less gas increased 1.7% in 2008, fell 6.9% in
2009, and increased 3.7% in 2010.
